Serveur d'exploration sur la grippe aux Pays-Bas

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[Influenza season 1998/99; composition of vaccine for 1999/2000].

Identifieur interne : 000450 ( Main/Exploration ); précédent : 000449; suivant : 000451

[Influenza season 1998/99; composition of vaccine for 1999/2000].

Auteurs : G F Rimmelzwaan [Pays-Bas] ; J C De Jong ; A I Bartelds ; J W Dorigo-Zetsma ; R A Fouchier ; A D Osterhaus

Source :

RBID : pubmed:10535060

Descripteurs français

English descriptors

Abstract

The first indication of influenza activity in the Netherlands in the 1998/'99 season was the isolation of an influenza B virus in week 47 of 1998. In subsequent weeks influenza activity slowly increased, reaching a peak in week 6 of 1999. After a gradual decline for three weeks a second peak was reached in week 8 of 1999. The first wave of influenza activity was primarily caused by influenza B viruses, whereas during the second wave predominantly influenza A viruses of the A/H3N2 subtype were isolated. The antigenic properties of the influenza A viruses resembled those of the viruses isolated in the previous season and the vaccine strain A/Sydney/5/97. The influenza B viruses did not completely match with B/Harbin/7/94 which is most commonly used for vaccine production. The vaccine, however, did provide good protection against the epidemic strains of influenza. This season influenza A/H1N1 viruses did not play a significant part and only a small number of viruses of this subtype were isolated at the end of the season. For the influenza season 1999/2000 it is recommended by the World Health Organization that the vaccines contain the following (or similar) virus strains: A/Sydney/5/97 (H3N2), A/Beijing/262/95 (H1N1) and B/Beijing/184/93.

PubMed: 10535060


Affiliations:


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Le document en format XML

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<nlm:affiliation>Nationaal Influenza Centrum van de Wereldgezondheidsorganisatie, Erasmus Universiteit, afd. Virologie, Rotterdam.</nlm:affiliation>
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<div type="abstract" xml:lang="en">The first indication of influenza activity in the Netherlands in the 1998/'99 season was the isolation of an influenza B virus in week 47 of 1998. In subsequent weeks influenza activity slowly increased, reaching a peak in week 6 of 1999. After a gradual decline for three weeks a second peak was reached in week 8 of 1999. The first wave of influenza activity was primarily caused by influenza B viruses, whereas during the second wave predominantly influenza A viruses of the A/H3N2 subtype were isolated. The antigenic properties of the influenza A viruses resembled those of the viruses isolated in the previous season and the vaccine strain A/Sydney/5/97. The influenza B viruses did not completely match with B/Harbin/7/94 which is most commonly used for vaccine production. The vaccine, however, did provide good protection against the epidemic strains of influenza. This season influenza A/H1N1 viruses did not play a significant part and only a small number of viruses of this subtype were isolated at the end of the season. For the influenza season 1999/2000 it is recommended by the World Health Organization that the vaccines contain the following (or similar) virus strains: A/Sydney/5/97 (H3N2), A/Beijing/262/95 (H1N1) and B/Beijing/184/93.</div>
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